Number of Lynch syndrome families and individuals by cancer status by continent that can be contributed by the International Mismatch Repair Consortium.
Total | Austral-asia | Europe | North America | Asia | South America | Africa | |
Centres | 59 | 11 | 18 | 20 | 5 | 4 | 1 |
Families | 8863 | 1035 | 4724 | 2368 | 541 | 115 | 80 |
MLH1 |
3384 | 326 | 1979 | 756 | 222 | 61 | 40 |
MSH2 |
3988 | 440 | 2098 | 1121 | 253 | 51 | 25 |
MSH6 |
1109 | 174 | 549 | 310 | 58 | 3 | 15 |
PMS2 |
382 | 95 | 98 | 181 | 8 | 0 | 0 |
Population-based | 2848 | 89 | 1792 | 386 | 222 | 53 | 0 |
Clinic-based | 6015 | 946 | 2932 | 1982 | 319 | 62 | 80 |
Mutation carriers | 20434 | 3225 | 10924 | 5479 | 799 | 53 | 634 |
Cancers | 12827 | 2951 | 5742 | 4340 | 656 | 51 | 508 |
Colorectal | 9711 | 1692 | 4469 | 3561 | 488 | 50 | 244 |
Endometrial | 7638 | 1201 | 3532 | 2651 | 504 | 49 | 206 |
Ovarian | 2808 | 298 | 1408 | 1093 | 97 | 3 | 18 |
Kidney | 830 | 70 | 351 | 463 | 16 | 3 | 2 |
Pancreas | 373 | 48 | 150 | 219 | 2 | 0 | 4 |
Gastric | 115 | 10 | 51 | 53 | 4 | 1 | 4 |
Prostate | 492 | 82 | 246 | 163 | 16 | 1 | 16 |
Other | 226 | 34 | 95 | 112 | 9 | 0 | 0 |